Automation Applications
To better illustrate what LEAP has accomplished over the last few years by using the CTC PAL as a Platform LEAP has created a separate website, LEAPwiki.com, which acts as a database for such Applications. Visit LEAPwiki.com for more CTC PAL applications.
LEAP is experienced in providing automation solutions for any process that gathers, treats and delivers samples to an analytical process. Liquid Handling is in most cases involved but we are not limited to that. We can also move, weight and image objects. Liquid handling includes spraying and printing besides the usual measuring, pipetting, injecting, mixing, heating or sampling of a variety of liquids. We have the ability to design, engineer, deliver and support simple but unique or complex but simple to use systems.
The LEAP Shell 3 software let’s us create solution specific sample lists and Shell 3 methods that synchronizes all instruments involved. We can provide complete locked-down systems to Value Added Resellers (VARs).
Combinations of instruments that we can supply are robotic sampling devices and LC pumps as front-end to LC-MS systems. Single and dual channel LC to one MS that save cycle time and therefore increase throughput are becoming standard Frontend Automation Bundles (FABs).
Sample Handling Automation: On-Line, Off-Line, At-Line For LC, GC, MS
Let us show you how automation can make your life in the laboratory easier, more efficient, and more rewarding.
LEAP strives to find custom solutions for all industries using analytical processes for small and large molecules in extracted liquids, solids, and in human, animal and plant tissues. We provide the precise robotics and efficient sample prep required by modern measurement techniques such as mass spectroscopy.
Automate Your Method With Over 50 Accessories
Including: Injecting, Filtering, Pumping, Sample Picking, Reagent Adding, CCD Imaging (Camera), Agitating, Diluting, Monitoring, LC/MS Screening, Vortexing, Fractionating, Customizing, Drying, Digesting, Gel Plug Monitoring, Pre-piercing, Barcode Reading, Moving Vials, Re-injecting, Extracting, Heating, Derivatizing, Reformatting, Column Switching, Vial Transporting, Sample Tracking, Synchronizing, Fraction Tracking, Spot Cutting, Sample Handling, Evaporating, Sample Purifying, Weighing, Saponifying, Cherry Picking, Shaking, Spraying, Painting
CTC PAL Application Solutions
- Analyzing a Plant Extract
- Balance PAL
- Biofuel Applications
- Direct Analysis in Real Time (DART®)
- GC Headspace
- Filtering of Samples
- Hydrogen Deuterium Exchange
- LC Multi-Valve Applications
- MALDI Applications
- NMR Sample Prep
- Polymer Analysis
- Process Monitoring Applications
- Purification Applications
- Radiolabeling
- Small Volume Fraction Collection
- Solid Phase Extraction
- SPME
LEAP Integrated Components
PAL Accessories and Options - a concept you can grow with for your CTC Autosampler
- Bar Code Reading
- Column Heating
- Cooling and Heating Sample Storage
- Filtering of Samples
- Large Volume Dispensing
- Mixing of Samples
- Unique Storage
- Unique Injections
- Valve Washing
Examples of Special Solutions
Examples of some customized applications LEAP has provided to it’s customers. We call them “LEAP Specials”. They are custom made to suit your exact needs. Let us show you how automation can make your life in the laboratory easier, more efficient, and more rewarding. Contact Us to learn more about how LEAP can customize an automated application for your needs.
- Analysis of Total Iodine
- A Flexible LCMS Front End for High-Throughput Bioanalytical Analysis in GLP Environment
- Automated online liquid chromatographic/mass spectrometric metabolic study for prodrug stability
- Detecting a Carcinogen in Alcohol Beverages
- Dilute and incubate sample prior to LC injection
- Dual Channel Sample Cleanup
- Forced Degradation - Dual PAL under LEAP Shell
- High SPEed for CTC PAL On-line Multidimensional SPE-SPE-LC of Raw Biofluids
- High Throughput Sample Analysis using Multiple Column LC/MS/MS and Automated Method Optimization Techniques
- Intrinsic Viscosity testing
- Increasing throughput of parallel on-line extraction liquid chromatography/electrospray ionization tandem mass spectrometry system for GLP quantitative bioanalysis in drug development
- Integrated high capacity solid phase extraction-MS/MS system for pharmaceutical profiling in drug discovery
- Kinetic Reaction with GC Injection
- Mass Spec based Purification System
- Multiplexing LC injections
- Multi-Valve system for selectable loop size
- One Step Derivitization
- Online Sample Cleanup using column switching with Multi-Valve system
- On-line SPE LC/MS/MS to Detect Organonitrogen and Triazine Pesticides in Drinking Water
- Pooling of vial contents for QC testing
- Productivity Package
- Rapid Precision Dispensing
- Sample Filtration with Whatman Mini-Uniprep Press
- Sandwich Technique for Small Sample Volumes
- Sharper peaks using 2-stage low sample dispersal injection technique
- Simultaneous Screen of 23 Drugs of Abuse by LC API MS MS
- Twin PAL - High Throughput injections using Cycle Composer
- Using the PAL Autosampler as a Syringe Pump for MS Tuning
Applications Publications and Posters
- A Flexible LCMS Front End for High-Throughput Bioanalytical Analysis in GLP Environment
- Automated online liquid chromatographic/mass spectrometric metabolic study for prodrug stability
- Automated Processing of 2-D Protein Gels
- Characterization of Human Gastric Cancer by MALDI Imaging
- Discovery of Biomarkers for Endometrial Carcinoma
- Increasing throughput of parallel on-line extraction liquid chromatography/electrospray ionization t
- Integrated high capacity solid phase extraction-MS/MS system for pharmaceutical profiling in drug di
LEAP Application Notes
- ATAS turns any GC into an analytical toolbox
- Dual Channel SPE TRIO VS with Aux port Valve on HTS
- High SPEed for CTC PAL - On-line multidimensional SPE-SPE-LC of Raw Biofluids
- LC-Injection With Derivitization/Agitation
- Sandwich technique for small sample volumes
- TRIOVS Dual Stream Staggered Injection
- Using the PAL Autosampler as a Syringe Pump for MS Tuning