LEAP’s TM iD featured in ASMS 2005 poster

Discovery of Biomarkers for Endometrial Carcinoma by Direct Profiling of Proteins in Tissue Sections Using Selective MALDI-SPOTTING and MALDI MS

Jingzhong Guo (1); Muntajib Alhaq (2); Leroi V. DeSouza (1); Gordon Nye (3); Werner Martin (3); Alexander D. Romaschin (4); Terence J. Colgan (2); K..W. Michael Siu (1) 1 York University, Toronto, ON, Canada; 2 Mount Sinai Hospital, Toronto, ON, Canada; 3 LEAP Technologies, Inc., Carrboro, NC; 4 Toronto General Hospital, Toronto, ON, Canada

Overview Purpose: Discovering biomarkers for endometrial carcinoma rapidly by direct profiling of proteins in tissue sections.

Methods: nano-scale MALDI-Spotting and MALDI QqTOF mass spectrometry.

Results: Five up-regulated protein markers for endometrial carcinoma were discovered with the new tool.